Preprint reviews by Patrick Mineault

Testing pseudo-linear models of responses to natural scenes in primate retina

Alexander Heitman, Nora Brackbill, Martin Greschner, Alexander Sher, Alan M. Litke, E.J. Chichilnisky

Review posted on 28th July 2016

I appreciate the very narrow point that the authors are making - i.e. that a certain class of GLM-like models doesn't work very well when it comes to explaining RGC responses to natural stimuli -, but I feel like the claim that "retinal signaling

under natural conditions cannot be captured by models that begin with linear filtering" is a bit too broad.

First, a very simple two subunit-model qualifies as a "model which begins with linear filter"; e.g. two linear subunits, followed by a pointwise nonlinearity, then combined linearly and followed by another pointwise nonlinearity. Dan Butts (McFarland at al. 2011, J Neurosci) showed that that goes a long way in explaining variability in LGN cells in response to natural stimuli (http://neurotheory.umd.edu/Pub..., and one would presume would resolve some of the deficiencies in the RGC models.

Second, the claim that '[these findings] emphasize the importance of additional spatial nonlinearities, gain control, and/or peripheral effects in the first stage of visual processing." is both a bit strong and a lost opportunity. It makes it sound like GLMs and GLM+s are so deficient that you're going to need to throw the kitchen sink at the problem to explain natural image responses. Why not fit a simple subunit model and see if that helps? Then that will help us understand the limits of the current model and how much extra modeling really needs to be done to explain natural movie responses. The code is available for this (http://neurotheory.umd.edu/nim..., it seems like a pretty low-hanging fruit.

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